IJBHTM 2016 Volume 6 Issue 2
International Journal of BioSciences, Healthcare Technology and Management (IJBHTM) ISSN: 0975-3893
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Growth Factors and Cytokines Secreted in Conditioned Media by Mesenchymal Stem Cells – Promising Possible Therapeutic Approach for Hair Regeneration. Sushilkumar Ramdasi. IJBHTM (2016), 6(2):9-19
Title:
Growth Factors and Cytokines Secreted in Conditioned Media by Mesenchymal Stem Cells – Promising Possible Therapeutic Approach for Hair Regeneration
Authors & Affiliation:
Sushilkumar Ramdasi
Research Scholar, Faculty of Sciences, Pacific Academy of Higher Education and Research University, Udaipur, India
E-mail: sushbiotech@gmail.com Mobile: +91-9987502130
Abstract:
The present treatment options for hair loss are drugs (Finasteride and Minoxidil), laser therapy, follicular hair transplant, and serum therapy. These treatments have their own side effects and contraindications with appropriate alerts from regulatory authorities. The side effects imposed by these treatment options cannot be neglected and demands alternate therapy approach with less or no side effects. Hair loss can have major psychological impact on affected individuals belonging to varied ethnicity. Hair itself is a mini organ and serves many significant functions like maintaining body temperature and promoting social interactions. Hair recycling is continuous process governed by hair growth cycle consisting of three phases viz. anagen, catagen and telogen. Imbalance of any sort in the normal cycle due to any reason results into un-healthy hair or complete stagnation of hair growth. Major factor contributing to hair loss is androgenic alopecia. Hair follicles possess receptor for androgen and DHT (Dihydrotestosterone) in excess results into shrinkage of hair follicle affecting hair growth adversely. Stem cell therapy is one of the promising therapeutic modality in near future. Use of stem cells as a therapeutic strategy has many advantages over conventional therapies for hair growth. Adult human possess stem cells in body parts like bone marrow and adipose tissue. Stem cells extracted from patient for hair regeneration application rules out immunological rejection and other side effects. If fact, mesenchymal stem cells are immune privileged and hence devoid of any histocompatibility requirements. The present article reviews reasons for hair loss, conventional treatment options and their side effects, unique properties of stem cells, growth factors secreted by stem cells for hair regeneration and experimental strategies to up-regulate secretion of favourable growth factors for hair regeneration.
KEY WORDS: Hair loss, Androgenic alopecia, conditioned medium, stem cells, MSCs